What causes hATTR amyloidosis?
Hereditary ATTR (hATTR) amyloidosis is caused by an inherited gene change (mutation). This affects the function of a protein called transthyretin (TTR), which is made primarily in the liver and carries substances such as vitamin A.
How hATTR amyloidosis develops
Abnormal TTR
Abnormal TTR
A change within a gene causes TTR, a protein made mostly in the liver, to take on an abnormal shape.
Amyloid deposits
Amyloid deposits
This results in the buildup of clustered proteins, known as amyloid deposits, throughout the body over time.
Symptoms of hATTR amyloidosis
Symptoms of hATTR amyloidosis
The buildup of amyloid deposits leads to symptoms that can affect different parts of the body, including the nerves, heart, and digestive system. The damage caused by this disease can be disabling and life-threatening.
Your family and hereditary ATTR amyloidosis
A brochure to help guide important discussions with family and loved ones
